Rejuran®:

Salmon DNA Skin Regeneration 

Rejuran (also known as Rejuran Healer or PN/PDRN skin booster) is a popular skin rejuvenation treatment that originated in South Korea.

It uses highly purified polynucleotides (PN) or polydeoxyribonucleotides (PDRN) — short DNA fragments extracted from wild salmon sperm — to repair and regenerate skin at a cellular level.

Unlike traditional dermal volumisers (which add volume) or anti-wrinkle treatments (which relaxes muscles), Rejuran acts as a biostimulator. It triggers your skin’s natural healing processes without adding significant volume, making it ideal for improving overall skin quality rather than contouring.

How Rejuran Works

The key ingredient, PN/PDRN, is highly biocompatible with human DNA. When injected into the dermis (the middle layer of the skin), it works through several mechanisms:

  • Stimulates fibroblasts (the cells that produce collagen and elastin) via activation of adenosine A2A receptors.

  • Promotes collagen and elastin synthesis, strengthening the extracellular matrix.

  • Enhances wound healing and tissue repair by increasing growth factors, improving microcirculation (angiogenesis via VEGF), and reducing inflammation.

  • Provides building blocks for new DNA synthesis and acts as a scaffold for cell growth.

  • Boosts hydration and skin barrier function over time.

Results develop gradually as your skin regenerates — you won’t see instant plumping, but rather progressive improvements in texture, firmness, and glow.

Main Benefits

Rejuran is commonly used for:

  • Improving skin elasticity and firmness (reducing fine lines and mild sagging).

  • Smoothing texture and reducing enlarged pores or acne scars.

  • Enhancing hydration and giving a “glass skin” glow.

  • Repairing damaged skin (e.g., from sun exposure, inflammation, or aging).

  • Evening skin tone and reducing redness or dullness.

  • Supporting overall skin healing and anti-inflammatory effects.

  • $500 per treatment

  • $750 per treatment

  • $550 Per Treatment

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  • REJURAN® is a sterile injectable gel containing sodium polynucleotide, administered into the dermis by a trained healthcare professional to promote tissue restoration, reconstruction, and improvement of physical appearance (ARTG ID 412630).

  • REJURAN PN are DNA fragments of a specific size, extracted and purified from wild salmon using PharmaResearch's proprietary DNA Optimising Technology (DOT™).

    REJURAN PN are a longer and more concentrated form of PDRN (Polydeoxyribonucleotide or salmon sperm-derived DNA).

  • REJURAN® may be suitable for individuals looking to support the appearance of their facial skin. It is typically used by a qualified health practitioner as part of a personalised treatment plan, to promote tissue restoration and reconstruction.

    Individual results vary and suitability for treatment depends on individual skin needs, expectations, and medical history. A consultation with a qualified health practitioner is essential to determine whether REJURAN® is appropriate for you and to discuss potential outcomes, risks, and aftercare.

  • REJURAN® is not a one-size-fits-all solution — individual treatment plans and results vary, including the number of treatments that may be required. A consultation with a qualified healthcare professional is essential to determine whether the treatment is right for you, how it should be personalised, and to understand post-treatment care and potential side effects.

    Book a consult to learn more.

  • Some individuals may experience temporary skin changes, such as swelling, redness, itching, dryness, flaking or papules following treatment. These generally resolve soon afterwards.

    Your healthcare professional will provide tailored aftercare guidance, which may include avoiding heat exposure (e.g. saunas, steam rooms) and intense physical activity for a short period to support comfort and recovery. It is also recommended to avoid pressing or massaging the treated area for 24–48 hours. Daily use of a high-SPF, broad-spectrum sunscreen can help protect skin from UV exposure.

    Individual responses to treatment vary. Consultation with a qualified healthcare professional is important for personalised advice and to understand possible effects.

  • REJURAN® treatment may be applied to various areas of the face - including the forehead, temples, cheeks and around the mouth, or the delicate under-eye area - depending on individual need.

    REJURAN® treatments may be administered by trained professionals, and are only provided following an individual consultation to determine suitability.

  • Some individuals may experience temporary skin changes, such as swelling, redness, itching, dryness, flaking or papules following treatment. These generally resolve soon afterwards.

    REJURAN® is not a one-size-fits-all solution — individual results vary. A thorough consultation with a qualified healthcare professional is essential to determine post-treatment care and any potential side effects.

  • REJURAN® Classic is a professionally administered procedure designed for use across various areas of the face.

    If deemed suitable by a qualified healthcare professional, the skin is cleansed, and a topical anaesthetic (numbing cream) may be applied to enhance comfort. REJURAN® Classic is then carefully administered. The procedure usually takes around 30 minutes. Some mild redness, swelling, or small bumps may occur, and generally resolve shortly after.

    A consultation with your healthcare provider is required to assess your suitability and discuss what to expect before and after treatment.

  • REJURAN® may be combined with other aesthetic treatments, depending on individual needs and goals.

    A consultation with a qualified healthcare professional is required to assess your suitability and any potential risks of combining treatments. Individual results and experiences may vary.

  • REJURAN® i is less viscous than REJURAN® Classic, making it suitable for use in delicate areas such as the under-eye region.

    It is administered by a qualified healthcare professional and may be recommended as part of an individualised treatment plan to support smoother-looking skin.

    A consultation with your practitioner is required to assess suitability. Results and experiences may vary.

  • After a REJURAN® i treatment, you may experience some temporary redness, swelling, or small bumps.

    These effects are generally mild and tend to resolve within a few hours to a couple of days. Most people can return to normal daily activities shortly after the procedure.

    Your healthcare professional will provide tailored aftercare instructions. A consultation is essential to understand what to expect based on your skin type and treatment plan, as individual experiences may vary.